differential equations - Having trouble using WhenEvent with NDSolve

First of all, this is my first time on this forum. Please be patient with me because if I make some mistakes in this post. I'm not used to doing this!

I'm trying to modify a parameter during NDSolve iterations. I tried to follow advice given in the following exchanges:

But none of it seems to fit my problem. Perhaps I'm doing something wrong.

Here is my problem:

I'm currently trying to create a model with the following differential equations:

dEc = p1*Ec[t]*(1 - (Ec[t]/Emax)) - d1*Ec[t] - i1*Ic[t]*Ec[t];
dIc = i1*Ic[t]*Ec[t] - u1*Ic[t];
dVp = ist*b1*u1*Ic[t] - c1*Vp[t];

The parameters are defined as following:

parameters = 
  {Emax ->  10000, p1 ->  0.6, d1 ->  0.003, u1 ->  0.33, c1 ->  10, 

   b1 ->  6000, i1 ->  0.0000002, ist ->  0.0001};

Then, I'm doing the following NDSolve:

dynamicsmodel = 
  NDSolve[
    Evaluate[
      {Ec'[t] == dEc, Ic'[t] == dIc, Vp'[t] == dVp, 
       Ec[0] == 10000, Ic[0] == 0, Vp[0] == 10}] /. parameters,
  {Ec[t], Ic[t], Vp[t]},
  {t, 0, 300}]

It seems to work perfectly. But I would like to add an event listener that would change the ist parameter when t >= 200. To do so, I tried with the following code:

dynamicsmodel = 
  NDSolve[
    Evaluate[
      {Ec'[t] == dEc, Ic'[t] == dIc, Vp'[t] == dVp, 
       Ec[0] == 10000, Ic[0] == 0, Vp[0] == 10}] /. parameters,
    WhenEvent[t >= 200, parameters[[8]] = ist -> 0.01],
  {Ec[t], Ic[t], Vp[t]},
  {t, 0, 300}]

But it doesn't seem to work! I get the following error:

To avoid possible ambiguity, the arguments of the dependent variable in WhenEvent[t >= 200, parameters[[8]] = ist -> 0.01] should literally match the independent variables."

I may have misplaced the WhenEvent. I tried to put it inside of the Evaluate expression, but that produces errors.

Please note that I simplified the code to make it more readable. I hope I didn't introduce errors.

Answer

I believe you need to take ist out of parameters and make it a DiscreteVariable in the NDSolve. This seems to work:

dEc := p1*Ec[t]*(1 - (Ec[t]/Emax)) - d1*Ec[t] - i1*Ic[t]*Ec[t];

dIc := i1*Ic[t]*Ec[t] - u1*Ic[t];
dVp := ist[t]*b1*u1*Ic[t] - c1*Vp[t];

parameters = {Emax -> 10000, p1 -> 0.6, d1 -> 0.003, u1 -> 0.33, c1 -> 10, b1 -> 6000, i1 -> 0.0000002};

dynamicsmodel = NDSolve[{
  Ec'[t] == dEc, Ic'[t] == dIc, Vp'[t] == dVp, 
  Ec[0] == 10000, Ic[0] == 0, Vp[0] == 10, ist[0] == 0.0001, 
  WhenEvent[t == 200, ist[t] -> 0.01]} /. parameters,
  {Ec, Ic, Vp, ist}, {t, 0, 300}, DiscreteVariables -> {ist}][[1]];

GraphicsGrid[{{
   Plot[Evaluate[Ec[t] /. dynamicsmodel], {t, 0, 300}, PlotRange -> All, PlotLabel -> Ec],
   Plot[Evaluate[Ic[t] /. dynamicsmodel], {t, 0, 300}, PlotRange -> All, PlotLabel -> Ic]},
  {Plot[Evaluate[Vp[t] /. dynamicsmodel], {t, 0, 300}, PlotRange -> All, PlotLabel -> Vp],
   Plot[Evaluate[ist[t] /. dynamicsmodel], {t, 0, 300}, PlotRange -> All, PlotLabel -> ist]
   }}, ImageSize -> 600]

Kind of underwhelming though -- maybe different parameters would be more interesting!

As a side note, I like to omit the [t] in the list of dependent variables.